Shortcuts
Top of page (Alt+0)
Page content (Alt+9)
Page menu (Alt+8)
Your browser does not support javascript, some WebOpac functionallity will not be available.
.
Default
.
PageMenu
-
Main Menu
-
Simple Search
.
Advanced Search
.
Journal Search
.
Refine Search Results
.
Preferences
.
Search Menu
Simple Search
.
Advanced Search
.
New Items Search
.
Journal Search
.
Refine Search Results
.
Bottom Menu
Help
Italian
.
English
.
German
.
New Item Menu
New Items Search
.
New Items List
.
Links
SISSA Library
.
ICTP library
.
Italian National web catalog (SBN)
.
Trieste University web catalog
.
Udine University web catalog
.
© LIBERO v6.4.1sp220816
Page content
You are here
:
Catalogue Tag Display
Catalogue Tag Display
MARC 21
Targeted Cancer Treatment in Silico: Small Molecule Inhibitors and Oncolytic Viruses
Tag
Description
020
$a9781461483014
082
$a570.285
099
$aOnline Resource: Springer
100
$aKomarova, Natalia L.
245
$aTargeted Cancer Treatment in Silico$h[EBook]$bSmall Molecule Inhibitors and Oncolytic Viruses$cby Natalia L. Komarova, Dominik Wodarz.
264
$aNew York, NY$bBirkhäuser$c2014.
300
$aXV, 227 pages: 71 illus., 26 illus. in color.$bonline resource.
336
$atext
338
$aonline resource
505
$a
Background and Scope of the Book -- Part I Treatment of Cancer with Small Molecule Inhibitors -- An Introduction to Small Molecule Inhibitors and Chronic Myeloid Leukemia -- Basic Dynamics of Chronic Myeloid Leukemia During Imatinib Treatment -- Stochastic Modeling of Cellular Growth, Treatment, and Resistance Generation -- Evolutionary Dynamics of Drug Resistant Mutants in Targeted Treatment of CML -- Effect of Cellular Quiescence on the Evolution of Drug Resistance in CML -- Combination Therapies: Short term versus Long term Strategies -- Cross Resistance: Treatment and Modeling -- Mathematical Modeling of Cyclic Cancer Treatments -- Part II Treatment of Cancer with Oncolytic Viruses -- Introduction to Oncolytic Viruses -- Basic Dynamics of Oncolytic Viruses -- Mitotic Virus Transmission and Immune Responses -- Axiomatic Approaches to Oncolytic Virus Modeling -- Spatial Oncolytic Virus Dynamics -- Oncolytic Viruses and the Eradication of Drug-resistant Tumor Cells.
520
$a
This monograph provides the first in-depth study of how mathematical and computational approaches can be used to advance our understanding of cancer therapies and to improve treatment design and outcome. Over the past century, the search for a cancer cure has been a primary occupation of medical researchers. So far, it has led to a wide range of treatment techniques, including surgery, chemo- and radiotherapy, antiangiogenic drugs, and most recently, small molecule inhibitors and oncolytic viruses. Each treatment tends to have a certain effectiveness in a specific class of patients, but it is often unclear what exactly causes it to succeed or fail. Recent technological advances have given rise to an ever increasing pool of data and information that highlight the complexity underlying the cancers and their response to treatment. Next to experimental and clinical research, mathematical and computational approaches are becoming an indispensible tool to understand this complexity. Targeted Cancer Treatment in Silico is organized into two parts, corresponding to two types of targeted cancer treatment: small molecule inhibitors and oncolytic viruses. In each part, the authors provide a brief overview of the treatment’s biological basis and present the mathematical methods most suitable for modeling it. Additionally, they discuss how these methods can be applied to answer relevant questions about treatment mechanisms and propose modifications to treatment approaches that may potentially increase success rates. The book is intended for both the applied mathematics and experimental oncology communities, as mathematical models are becoming an increasingly important supplement to laboratory biology in the fight against cancer. Written at a level that generally requires little technical background, it will be a valuable resource for scientists and graduate students alike, and can also serve as an upper-division undergraduate or graduate textbook.
538
$aOnline access to this digital book is restricted to subscription institutions through IP address (only for SISSA internal users)
700
$aWodarz, Dominik.$eauthor.
710
$aSpringerLink (Online service)
830
$aModeling and Simulation in Science, Engineering and Technology,
856
$u
http://dx.doi.org/10.1007/978-1-4614-8301-4
Quick Search
Search for