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Design and Analysis of Subgroups with Biopharmaceutical Applications

Design and Analysis of Subgroups with Biopharmaceutical Applications
Catalogue Information
Field name Details
Dewey Class 519.5
Title Design and Analysis of Subgroups with Biopharmaceutical Applications ([EBook]) / edited by Naitee Ting, Joseph C. Cappelleri, Shuyen Ho, (Din) Ding-Geng Chen.
Added Personal Name Ting, Naitee
Cappelleri, Joseph C.
Ho, Shuyen
Chen, (Din) Ding-Geng
Other name(s) SpringerLink (Online service)
Edition statement 1st ed. 2020.
Publication Cham : : Springer International Publishing : : Imprint: Springer, , 2020.
Physical Details XVIII, 400 p. 61 illus., 43 illus. in color. : online resource.
Series Emerging Topics in Statistics and Biostatistics 2524-7735
ISBN 9783030401054
Summary Note This book provides an overview of the theories and applications on subgroups in the biopharmaceutical industry. Drawing from a range of expert perspectives in academia and industry, this collection offers an overarching dialogue about recent advances in biopharmaceutical applications, novel statistical and methodological developments, and potential future directions. The volume covers topics in subgroups in clinical trial design; subgroup identification and personalized medicine; and general issues in subgroup analyses, including regulatory ones. Included chapters present current methods, theories, and case applications in the diverse field of subgroup application and analysis. Offering timely perspectives from a range of authoritative sources, the volume is designed to have wide appeal to professionals in the pharmaceutical industry and to graduate students and researchers in academe and government.:
Contents note 1. Data-driven and Confirmatory Subgroup Analysis in Clinical Trials -- 2. Subgroup Analysis - A View from Industry -- 3. Biomarker-Targeted Confirmatory Trials -- 4. Considerations on Subgroup Analysis in Design and Analysis of Multi-Regional Clinical Trials -- 5. Practical Subgroup Identification Strategies in Late-stage Clinical Trials -- 6. Exploratory Subgroup Identification for Biopharmaceutical Development -- 7. Logical Inference on Treatment Efficacy When Subgroup Exists -- 8. The GUIDE Approach to Subgroup Identification and Inference -- 9. Use of the VG (Virtual Twins Combined with GUIDE) Method in the Development of Precision Medicines -- 10. Subgroups Identification for Tailored Therapies: a System of Methods, a Framework for Consistent Methodology Evaluation, and an Integrated Learn-and-confirm Approach -- 11. Developing and Validating Predictive Classifiers in Randomized Clinical Trials -- 12. Issues Related to Subgroup Analysis -- 13. Subgroup Analysis with Partial Linear Model -- 14. Subgroup Analysis in the 21st Century -- 15. Power of Statistical Tests for Subgroup Analysis in Meta-Analysis -- 16. Heterogeneity and Subgroup Analysis in Network Meta-Analysis.
Mode of acces to digital resource Digital book. Cham Springer Nature 2020. - Mode of access: World Wide Web. System requirements: Internet Explorer 6.0 (or higher) or Firefox 2.0 (or higher). Available as searchable text in PDF format
System details note - Online access to this digital book is restricted to subscription institutions through IP address (only for SISSA internal users).
Internet Site https://doi.org/10.1007/978-3-030-40105-4
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